Baking Soda before Mitomycin installation

Yes, the new protocol is to dehydrate the night before. Take a half

Nordicat,

Thank you for the information. I found the links to be very interesting. I was not aware of these studies. I will continue to investigate these findings.

Thanks again.

Mark

<em>"While mitomycin C is highly effective, like doxorubicin it should never be given if bladder perforation is suspected. In a randomized study, recurrence was nearly cut in half by using an optimized schedule: 40 mg/20 cc (compared with 20 mg/20 cc), overnight dehydration, ultrasound-confirmed complete bladder emptying, alkalinization using 1.3 g of sodium bicarbonate the night before, morning of, and 30 minutes prior to treatment. Mitomycin C is inactivated by acid urine (Au et al. 2001)."</em>

www.medscape.com/viewarticle/514530_3

I guess I'll continue to alkalize before my treatments.

Mouth swishing with with baking soda is not for Mitomycin intravesical (instillation) therapy.


www.ncbi.nlm.nih.gov/pubmed/21239010

jnci.oxfordjournals.org/content/93/8/597.full

books.google.se/books?id=7PARDnCblAMC&pg=PA193&lpg=PA193&dq=mitomycin+alkalization&source=bl&ots=oFhV5w7yXb&sig=dWbJex1MGHoNyqJD9DuK1pILA-s&hl=sv&sa=X&ei=KgSNT-emHIj_4QS408GYDw&ved=0CF0Q6AEwBw#v=onepage&q=mitomycin%20alkalization&f=false

Nordicat,

The baking soda is only used if you develop cold sores in your mouth. If you do you can treat them with a mixture of 1 1/2 tsp of baking soda to 8oz of water, that you rinse your mouth out with.

It is not part of the treatment with Mitomycin.

Here is a link to ChemoCare.com web site with more information.

www.chemocare.com/bio/mitomycin.asp

I hope this clears things up for you.

Mark

It doesn't seem to be something done in this country but is advocated in many research programs in the US. Since Mitomycin's effects is greatly reduced in an acid environment, I think it's safe to bring my ph up to the normal 7, instead of its normal 5.6-6 which is too acid. I was just wondering if anyone had experience with it but no one seems to. I'll keep looking. Thanks.