I’d like to hear your thoughts and experience with third line treatments. But first a little background. January 2007 radical cystoprostatectomy and creation of neobladder. Tumor was into but not through the muscle wall. Three nodes were malignant. Between March 2007 and June 2007 completed Gemcitabine/Cisplatin treatment. Scans were clear until April 2008 when a new node in the left iliac chain was identified. Node was inaccessible to biopsy. Subsequently entered a clinical trial combining dosetaxel plus Zactima (an oral VEGF inhibitor) or placebo. In June 2008, after two cycles scans showed node was increasing in size. Unblinded in study and found to be on dosetaxel plus placebo. Then placed on Zactima and dosetaxel. Next month I have more scans.
Expecting the best but preparing for something less than that I’ll have choices to make. One of the probable choices will be between MVAC and Alimita. Which brings me back to my question – love to hear anyone’s experience with these treatments, especially as the third go round with chemo.
The link to the trial I’m in is
www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=562439&version=HealthProfessional&protocolsearchid=4865518
Its called Phase II Randomized Study of Docetaxel With Versus Without Vandetanib in Patients With Previously Treated Stage IV Transitional Cell Carcinoma
Thanks.