Paclitaxel-Hyaluronic Acid for Carcinoma In Situ

13 years 3 months ago #36429 by sara.anne
Replied by sara.anne on topic Paclitaxel-Hyaluronic Acid for Carcinoma In Situ
This study does not, of course, have anything to say about efficacy. It was a Phase I study which usually tests dose/toxicity of a new drug. Surprisingly, it was done on patients....usually Phase I is done on healthy volunteers.

Sara Anne

Diagnosis 2-08 Small papillary TCC; CIS
BCG; BCG maintenance
Vice-President, American Bladder Cancer Society
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13 years 3 months ago #36426 by mmc
Interesting. Looks like a potential 2nd line of defense if BCG doesn't work. I can't find anything on the efficacy of this treatment but from what I did find it seems they only recently started trying this on humans. Found some studies on mice from 2005.

Seems they are only looking at BCG refractory cases right now (those where BCG doesn't work) but it would be interesting to see how good this is when compared to BCG. From what I can find, it seems to have less complications than BCG but it may well be way to soon to come to that conclusion (although it seems promising based on the doses they used in this study not reaching a toxicity level).

Certainly sounds like a treatment to keep an eye on.

Thanks for posting this!
Mike

Age 54
10/31/06 dx CIS (TisG3) non-invasive (at 47)
9/19/08 TURB/TUIP dx Invasive T2G3
10/8/08 RC neobladder(at 49)
2/15/13 T4G3N3M1 distant metastases(at 53)
9/2013 finished chemo -cancer free again
1/2014 ct scan results....distant mets
2/2014 ct result...spread to liver, kidneys, and lymph...

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13 years 3 months ago #36423 by Cynthia
Paclitaxel-Hyaluronic Acid for Intravesical Therapy of Bacillus Calmette-Guérin Refractory Carcinoma In Situ of the Bladder: Results of a Phase I Study

P.F. Bassi, A. Volpe, D. D'Agostino, G. Palermo, D. Renier, S. Franchini, A. Rosato, M. Racioppi

www.jurology.com/article/PIIS0022534710047063/abstract?rss=yes

Cynthia Kinsella
T2 g3 CIS 8/04
Clinical Trial
Chemotherapy & Radiation 10/04-12/04
Chemotherapy 3/05-5/05
BCG 9/05-1-06
RC w/umbilical Indiana pouch 5/06
Left Nephrectomy 1/09
President American Bladder Cancer Society

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