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BCG Toxicity does not predict efficacy

12 years 2 weeks ago #2567 by Rosemary
I think I found the European study that Wendy was referring to in another thread about .....

"Maintenance BCG for Ta, T1 bladder tumors is not associated with inceased toxicity and side effects do not predict efficacy of BCG"

Sylvester R. V D Meijden

Similarly, Saint et al found no difference
in efficacy between patient with and
without adverse events. Thus while
controversial, the most recent evidence
suggests that BCG toxicity is not a
prognostic factor for treatment efficacy.
CONCLUSIONS
The majority of local and systemic side
effects are seen already during the
induction course in the first 6 months of
maintenance. After 6 months BCG
toxicity does not increase and
instillations are generally well tolerated.
While a correlation between BCG
toxicity and efficacy exists, our results do
not confirm that BCG toxicity is actually
responsible for an improved outcome.
Corresponding Author:
Prof. Dr. Adrian P. M. van der Mejden
Bosch Medical Center
Department of Urology


http://www.kup.at/kup/pdf/3843.pdf#search='bcg toxicity'

Rosemary
Age - 55
T1 G3 - Tumor free 2 yrs 3 months
Dx January 2006

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