Thermo-Chemotherapy available in the USA?

10 months 3 weeks ago #59866 by Sarag
Replied by Sarag on topic Thermo-Chemotherapy available in the USA?
Wow.

I thought it was much simpler than that.

So,how does kne know which treatment will most likely be more successful?

I have contacted Dr Lamm. I am making arrangements to be treated by him. Thank you immensely for giving me his name and contact information.
I can't begin to thank you adequately for your precious help.

Blessings,

Sara

Please Log in to join the conversation.

10 months 2 weeks ago #59874 by joea73
Replied by joea73 on topic Thermo-Chemotherapy available in the USA?
Glad to hear you were able to reach Dr. Lamm. Thanks to this forum and your postings and other people' postings it seems we were able to connect dots regarding Thermo-chemotherapy and gemcitabine & docetaxel. Refer to regarding non thermal gemcitabine & docetaxel in this forum. bladdercancersupport.org/forum/8-non-invasive-superficial-bladder-cancer-questions-and-comments/47198-switch-from-bcg-to-gemcitabine-and-docetaxel.html

Just to put in perspective, BCG therapy for bladder cancer was used in 1975 by Dr. Alvaro Morales of Queen's University in Canada. Dr. Michael O'Donnell of University of Iowa, who co-authored the study of gemcitabine & docetaxel sequential (non heated) treatment for BCG unresponsive is early pioneer for the treatment for non-muscle invasive bladder cancer. Dr. Donald Lamm, who co-authored the study by University of Arizon on gemcitabine & docetaxel sequential (heated) treatment for BCG unresponsive is also early pioneer for the treatment for non-muscle invasive bladder cancer- especially focused on BCG treatment. Below are some of newer generation of urologists who appear often in media on non-muscle-invasive bladder cancer treatment, i.e. Dr. Ashish Kamat of MD Anderson, Texas, Dr. Peter Black of University of British Columbia, Canada, Dr. Arjun Balar od NYU, Dr. Joshua Meeks of Northwestern University in Chicago, IL, etc.

The reason why I mentioned those names that in 2019, Dr. Balar and Dr. Black debated which recently approved treatment for BCG unresponsive is what they would recommend. One is Keytruda which is administered intravenously and Nanofaragene which is administered by catheter into bladder like BCG. We know how Keytruda how it works. Nanofaragra uses adenovirus as a vehicle to deliver the gene intereron alfa-2b into cells. Interferon alfa-2b has been used combined with BCG for those NMBIC patients whom BCG alone did not work.
Adenovirus is common cold virus. Adenovirus cotaining interferon alfa-2b gene penetrates into a cell. The cell will produce a protein interferon alfa-2b translating alfa-2b gene. Then interferon alpha-2b protein kill cancer cells.

Anyway, Keytruda and Nanofaragra showed similar efficacy, though more side effects on Keytruda. But the efficacy was not as good as they had hoped for. The complete response was 53% at 3 month, 24% at 12 month for Nanofaragra and it was 41% at 3 month 19% at 15 month for Keytruda. Anyway, they were aware of the study which reported a good result of gemcitabine and docetaxel. Dr. Black says "the numbers would suggest that it's better than either of these two drugs and it's inexpensive, easy to give, well-tolerated. I think we need to be very, very careful with that data and really need to go with trial data" The link below gives us an access to the video of the debate and trascript.

www.urotoday.com/video-lectures/bladder-cancer-expert-debates/video/mediaitem/1733-a-debate-on-the-management-of-bcg-unresponsive-cystectomy-ineligible-bladder-cancer-patient-pembrolizumab-vs-nadofaragene-firadenovec-arjun-balar-peter-black.html?pk_campaign=BalarBlack_SocialVideo_1733

Please Log in to join the conversation.

10 months 2 weeks ago #59875 by Sarag
Replied by Sarag on topic Thermo-Chemotherapy available in the USA?
Very very interesting. Thank you for the thorough and precious info.

Have you heard of Professor Thomas Seyfried? His treatment approach is radically different : cancee being a metabolical issue. Not a genetic one.

Thank you for everything to you Joea and to everyone who takes the time to reply to my posts. I appreciate it deeply.

Please Log in to join the conversation.

10 months 2 weeks ago #59876 by sara.anne
Replied by sara.anne on topic Thermo-Chemotherapy available in the USA?
I would be a little careful of putting too much faith in Thomas Seyfried's ideas. If you google him a bit you will find lots of issues with some of his theories. Haven't heard a lot about him lately, but he was quite a "buzzword" with his ketogenic diet ideas a number of years ago.

Sara Anne

Diagnosis 2-08 Small papillary TCC; CIS
BCG; BCG maintenance
Vice-President, American Bladder Cancer Society
Forum Moderator

Please Log in to join the conversation.

10 months 2 weeks ago #59877 by Sarag
Replied by Sarag on topic Thermo-Chemotherapy available in the USA?
I hear you. My mom has breast cancer (25 years battle). She adopted a very strict diet (Hypocrate center Palm Beach) but still needed chemo treatment. It is what it is.
Thank you.

Please Log in to join the conversation.

10 months 1 week ago #59901 by joea73
Replied by joea73 on topic Thermo-Chemotherapy available in the USA?
I had watched Professor Thomas Seyfried in Youtube awhile ago. What he concluded was that cancer was caused
by the disease in mitochondria and by focusing on mitochondria rather than DNA would lead to cure of cancer without introducing the toxicity in the current standard care. Though the word Metabolism encompasses a wide range of chemical reactions involved in maintaining the living state of the cells and the organism, it often refers to the processes of converting glucose molecule to energy by mitochondria. I think he knows the subject. But I think there is a flaw in how he establishes his points. II have listed the link to his talk. To fully understand what he is talking, it helps to explain terminologies he uses. I have attempted to explain them but I got stuck often because there are so many things I do not understand myself. But without some detail explanation of what's going on, we would not know to agree or disagree with his claim. So I will explain knowingly there will be errors.

First, our body is made of organs. an organ is made of chemical molecules. A chemical molecule is made of atoms. An atom is made of protons/neutrons & electrons. A chemical bonding is a lasting attraction between atoms, ions or molecules that enable the formation of chemical compounds. A chemical detachment is a detachment of atoms or molecules from a chemical compound which results in different chemical compounds.
It requires energy to bond atoms or molecules but when atoms or molecules are detached, it produce energy energy. Our body functions by using energy by bonding and detaching of atoms and molecules. A case in point is cell division. In order for a cell to divide into two cells, the cell first has to grow by creating two sets of everything in the cell then it splits into two cells. Those process takes much energy and perform. The energy is generated by bonding and detachment of atoms and molecules.

A cell is like a flexible ball. The cell is filled with a thick solution which is mainly composed of water, salts and proteins. The thick solution is called cytoplasm. Also inside the cell, there is the nucleolus in which 23 pairs of chromosomes are stored. Note that each chromosome contains a DNA. Also there are 1,000-2,000 mitochondria embedded in the cytoplasm. These mitochondria are called the power station and generate.

Metabolism to covert to a glucose to energy

Step 1. A glucose molecule enters a cell and into cytoplasm.
The glucose molecule composed of 6 carbon atoms, 12 hydrogen atoms and 6 oxygen
Step 2. Still inside cytoplasm, the glucose goes through first set of chemical reactions and generate 2 units of energy. The chemical reactions are called glycolysis and it does not use oxygen.
Step 3. The resulted chemical molecule enters mitochondria.
It goes through various chemical reactions and generate 36 units of energy.

Warburg Effects

In the 1920s, Otto Warburg showed that cultured tumour tissues have high rates of glucose uptake and lactate secretion, even in the presence of oxygen.

One of hallmarks of cancer is that it grows faster than normal tissue. Bladder consists epithelial tissue, connective tissue, muscle tissue and fat layer. The epithelial tissue of bladder consists of 3-6 layer of cuboidal cells stacked like layers of boxes. Those 3-6 layers of epithelial cells consist of the top part, middle part and bottom part. The cells on the top need to be replaced because it has tear and wear because they were being exposed urine and stretching for holding urine and contracting to excrete urine out from the bladder. A few studies show that they are replaced about every 40 days (mice). In general it takes 24 hours for a cell - normal or cancer - to divide into two. So, a bladder cell needs mitochondria to produce energy for the cell division every 41 days. But a cancer cell because it lost a function to wait 40 days for a cell division, it needs mitochondria to produce energy for the cell division 24x7. It means mitochondria must work harder and it needs more glucose and oxygen. I will show how this metabolic change is used in diagnostic.

I think one of Dr. Seyfried' idea to cure cancer is by intervening metabolism in mitochondria by reducing glucose, so mitochondria does not have enough glucose to produce energy which will be used by cancer cells. It sounds
like a good idea. But glucose es essential for producing energy for everything else in the body too. So he continues to day that the treatment must be done in very controlled manner. A concern is that chemical reactions are so interrelated and we do not know what will happen to our body if glucose intake is reduced for treating cancer and I think there have been no large studies done the impact of glucose reduction during cancer treatment except a few studies based on a small population and mice.

Mitochondria related diseases

Mitochondria has its own DNA and it is called mtDNA. It is not enclosed in a nucleous like DNA in a cell. Mitochondria has 16,500 DNA building blocks (base pair) compared to 3 billion building blocks of DNA in the cell. Mitochondria's DNA contain 37 genes which are used to make various proteins for various functions. DNA in the cell has 20,000- 25,000 genes.
DNA in Mitochondria (mtDNA) also mutates. The mutations are known to cause some disease. Typical disease caused by mutations in mtDNA are shown below. ( Dr. Marni Falk from the Children's Hospital of Philadelphia)

MELAS - mitrochondrial encephalopathy, lactice acidosis, and strokes
MERRF - myoclonic epilepsy with ragged red fibers
NARP - Neurogenic ataxia and retinitis pigmentosa
LHON - Leber Hereditary optic neuropathy

Dr. Falk says there are no FDA approved therapies or cures exist for Mitochondrial diseases.

She lists the reasons why theare are so few effective therapies.

1. Individually rare disorders - Highly heterogeneous genetic causes and clinical features
2. Excercise is beneficial (aerobic and isotonic)
3. No consensus of optimal diet into mito diseases
4. One-size-fits-all empiric "nutritional supplement cocktails" are variably used to theoretically assist mitochondrial enzymes and reduce celluar stress" - Support celluar metabolic activities & Antioxidants

I have noticed that university of Pennsylvanian and Harvard medical school have researches going on Mitochondria.

Please Log in to join the conversation.

Moderators: Cynthiaeddieksara.anne