Regor, I need to comment on your readings about CIS.
There is CIS and CIS. In some cases, particularly breast cancer where it is getting all the attention, something called "CIS" is indeed pre-cancer or maybe not cancer at all. There has been a lot of brough-ha-ha in the press about the "controversy" since most breast cancer surgeons seem to be recommending no treatment at all.
CIS in bladder cancer is totally different. It is a variant of uretheal carcinoma (the one that appears as little "mushrooms" growing up from the bladder surface.) Carcinoma in situ in the bladder appears as a sort of rash on the surface of the bladder. IT IS ALWAYS CONSIDERED HIGH GRADE and is especially dangerous for several reasons. First, because it is high grade, meaning that it has the potential to grow and spread relatively rapidly. Second, because it is not a discrete tumor, it is not possible to confidently remove it surgically, as in just cutting out the little mushrooms. We are very fortunate to have BCG available (when it IS available) since it has been shown to be very effective in the treatment of CIS.
In bladder cancer classifications, it is considered grade TIS.
Hope this clears things up a bit.
Sara Anne