BCG with Interferon

3 years 8 months ago #53968 by George9
BCG with Interferon was created by George9
Hi,

I have had two turbt's in the past 6 months. Had two rounds of BCG and it didn't work. Doc. wants me to do the BCG again, but with Interferon. Has anybody had this, and are there a lot of side effects, and did it work? I am new to this forum, so don't know if this had been asked before.

Thank you,
George

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3 years 8 months ago #53971 by Jack R
Replied by Jack R on topic BCG with Interferon
George,

Welcome to the forum. It is always ok to ask.

BCG with Interferon seems to have helped me more than BCG alone. I am hopeful that it, and other treatments will prove effective against CIS.

Adding interferon did not increase my already major BCG side effects. Others report a wide range of side effects - from minor to strong - it seems to be very individual thing.

Is yours papillary or CIS ? How many total BCG treatments ?

The link below is to a compiled article by Dr. Michael O'Donnell with an over view of his thoughts on interferon. He considers adding Interferon to be a positive thing.

You can use the search box and type in key words such as "interferon", and also visit the files area, or simply post questions to the group. I found this site a real asset when first diagnosed. No doctors here - just other patients with our own experiences.

Best,
Jack

thomaschallenger.com/wp-content/uploads/2011/10/Mike-ODonnell-Protocol-long.pdf

6/2015 HG Papillary & CIS
3 Years and 30 BCG/BCG+Inf
Tis CIS comes back.
BC clear as of 5/17 !
RCC found in my one & only kidney 10/17
Begin Chemo; Cisplatin and Gemzar
8/18 begin Chemo# 3
Begin year 4 with cis
2/19 Chemo #4
9/19 NED again :)
1/2020 CIS is back
Tried Keytruda, stopped by side effects
Workin on a new plan for 2021

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3 years 8 months ago #53974 by George9
Replied by George9 on topic BCG with Interferon
Hi Jack,

Thanks for answering this for me and for the link that you provided. I don't know exactly what you mean by CIS or Papillary. All I know is that it is high grade Urothelial Carcinoma. It was between the bladder lining and the muscle. It didn't penetrate the muscle, thank God. I had 6 wks. of BCG, followed by 6 wks. off, and then another six wks. Then the cystoscopy that showed another tumor. Ergo, the second surgery. I start the new treatment on 9/11 for 6 wks., followed by another cystoscopy. Doc. is going to do it in the o.r. instead of the office, in case there is another tumor and he can remove it right there. Not thrilled about going under general anesthesia again, but it is what it is.

Did you have surgery, or just the treatment? So, after the last treatment, is your tumor gone? My type almost always recurs, the high grade. Low grade don't usually come back.

Keep it touch,
George

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3 years 8 months ago #53975 by Jack R
Replied by Jack R on topic BCG with Interferon
George,

I wish you a good outcome on the upcoming treatment and evaluation.

I made an assumption that you have "superficial" bladder cancer, the most common type, of which papillary and CIS are the common variants. BCG is used for both.

Other cancers of the bladder exist, of which I have no knowledge - since my 2 year journey has been with both types of "superficial" cancer. Perhaps you have one of the other types ?

I am including another link, to a National Cancer Institute site, where a great deal of background info about bladder cancer is presented - the focus is on the "superficial" type, and includes discussions of treatments and differences in types. Papillary and CIS are covered as well.

www.cancer.gov/types/bladder

I have had multiple TURBTs - surgery to remove surface tumors from my bladder - all under general anesthesia. I have had both high and low grade, and both tend to reoccur. High grade has the nasty habit of progressing and escaping the bladder, but for me, so far, it has remained on the bladder surface - it goes away, then it comes back. Adding interferon "appears" to have kept it away, but time will tell if it remains gone.

None of my doctors have used the term "GONE". they say "controlled". I hope it remains controlled forever. I hope the same for you. (What does the second opinion doctor have to say for you ?)

Best
Jack

6/2015 HG Papillary & CIS
3 Years and 30 BCG/BCG+Inf
Tis CIS comes back.
BC clear as of 5/17 !
RCC found in my one & only kidney 10/17
Begin Chemo; Cisplatin and Gemzar
8/18 begin Chemo# 3
Begin year 4 with cis
2/19 Chemo #4
9/19 NED again :)
1/2020 CIS is back
Tried Keytruda, stopped by side effects
Workin on a new plan for 2021

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3 years 8 months ago #53976 by George9
Replied by George9 on topic BCG with Interferon
That is a great link you provided.

I haven't had a second opinion because I have complete faith in my urologist. Two of my coworkers have the same cancers, we worked at Sylvania and was exposed to every chemical known it seems. They each have different doctors, and we compare notes.

The choices seem to be the norm. Control with Turbts, BCG, or removal of the bladder. That will come with a whole slew of problems. I am a very young 77 in otherwise good health, so I am hoping that I can continue on this path. It gives me hope to know that the Interferon has helped you, I live in Ma, and we have some great facilities here, so lucky.

So, you are on a wait and see then?

Best to you too.

George

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3 years 7 months ago #54025 by VinceD
Replied by VinceD on topic BCG with Interferon
Jack,

Thanks for posting the link to the PDF. It is very informative. In April, I was diagnosed with Carcinoma In-situ, and did a 6 week cycle of BCG. At my check-up, 6 weeks after my last BCG instillation, my urologist told me the tumor, which covered my entire bladder, had been greatly reduced. However, he did see ~5-6 small spots of inflammation which he biopsied and CIS was still present. Today I started a 6 week cycle of BCG + interferon. The information you provided is similar to some things I have already read, and very encouraging. What is really nice are the recommendations for post treatment. Far better than what I've received from my urologist. I've been drinking quite a bit of fluid after treatments, but now understand that I might be overdoing it.

I am 46, with no prior history of cancer. Non-smoker, did not work around chemicals. Keeping my fingers crossed that this delivers the results that I need.

I wish you and George the best on your paths to recovery.

Vince

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