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Clarification please?

11 years 11 months ago #20947 by DIB
Thanks Ro - did miss your other post.

David

Male Dx T1G3 5/08 @ Age 59. TURBT 5/08; TURBT+40 mg MMC 6/08; BCG (6) 7/08-8/08; Cysto & TURBT 9/08; BCG Maint(3) 10/08, 3/09; 7/09; 11/09; 5/10; & 1/11. Clean cystos 2/09, 9/09, 3/10, & 10/10.

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11 years 11 months ago #20912 by Rosemary
Dave,

You asked this question before, and I answered it in another thread...
You must have missed it...

FISH is a Urine biomarker....

Re:whew! finally ! and a question for all 6 Days, 3 Hours ago
This definition of "FISH" was found at Web Cafe. I personally have never had the FISH test and don't know why...



QUOTE:
FISH - also on WebCafe: an expert P.F. Bassi, MD, reviews FISH

Florescence in situ hybridization (FISH) is an assay which uses a mixture of fluorescent labeled probes to assess urinary cells for chromosomal abnormalities associated with malignancy.

The FISH method detected cancerous cells in the urine of 81 percent of the patients with bladder cancer,” said Kevin Halling, M.D., a Mayo Clinic pathologist and lead researcher on the study. “By comparison, urine cytology detected cancerous cells in only 57 percent of the patients with bladder cancer. “Most importantly, the FISH test picked up more than 95 percent of the high grade cancers, which are the most dangerous and important group of bladder cancers because they have a high probability of progressing to potentially incurable muscle-invasive bladder cancer,” says Dr. Halling. “With only one exception, the only cancers the test missed were low-grade tumors, which are less dangerous and have only a 3 to 5 percent chance of progressing to a higher stage tumor over five years.” The FISH test also detected recurrence of the cancer three to six months earlier than by the cytology, says Dr. Halling. This earlier detection capability should allow treatment to be initiated earlier and possibly give the patient a greater chance for survival, he said


Here is the web link...

http://blcwebcafe.org/content/view/92/102/lang,english/
Please note, although no boardcode and smiley buttons are shown, they are still useable


Rosemary
Age - 55
T1 G3 - Tumor free 2 yrs 3 months
Dx January 2006

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11 years 11 months ago #20911 by DIB
Can someone please explain what is a FISH test and what does it analyze?

Thanks,
David

Male Dx T1G3 5/08 @ Age 59. TURBT 5/08; TURBT+40 mg MMC 6/08; BCG (6) 7/08-8/08; Cysto & TURBT 9/08; BCG Maint(3) 10/08, 3/09; 7/09; 11/09; 5/10; & 1/11. Clean cystos 2/09, 9/09, 3/10, & 10/10.

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11 years 11 months ago #20889 by Nix
I also had a FISH test, however mine came back negative even though I had 4 CIS spots removed two weeks later. My Uro said the FISH test is not always "spot-on",all the urine tests came back negative also.

Nancy S
Ta CIS
dx Ta 11/06
dx Ta CIS 10/07

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11 years 11 months ago #20877 by mmc
When my CIS was diagnosed 10/06, they called it CIS. It was described as red velvety area on the bladder wall about the size of my pinky finger from the tip to the first joint.

It was completely removed and I had no problem until last month.
Be sure to go to all of your follow up cysto's and get a FISH test every time you get a cysto.

Best of luck!

Age 54
10/31/06 dx CIS (TisG3) non-invasive (at 47)
9/19/08 TURB/TUIP dx Invasive T2G3
10/8/08 RC neobladder(at 49)
2/15/13 T4G3N3M1 distant metastases(at 53)
9/2013 finished chemo -cancer free again
1/2014 ct scan results....distant mets
2/2014 ct result...spread to liver, kidneys, and lymph...

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11 years 11 months ago #20774 by Nix
Hi,
My case (and .02 cents worth) CIS was considered a "flat head" tumor. It was red velvet spots. The first tumors removed were Ta Papillary (not sure if my spelling is correct) then 9 months later CIS was discovered during a 3 month cysto. I also thought CIS could treated and hopefully respond to BCG. I go next month for my 3 month cysto and that will also be my one yr. Hopefully, it will be clear. Of course, for the next week I will have my fingers and toes crossed :)

Nancy S
Ta CIS
dx Ta 11/06
dx Ta CIS 10/07

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