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BCG & Tuberculosis

12 years 8 months ago #12222 by drosenberg
Thanks, Rosemary & Warren. I did inform my uro, and he seemed unsure. It's likely the reason he wants to go the mitomycin route. I'll insist on a consult with an infectious disease person, if the subject of BCG comes up again.

Don

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12 years 8 months ago #12219 by wsilberstein

I have read that BCG is derived from a deactivated form of tuberculosis, or is related in some fashion to tuberculosis. Years ago, I tested positive for tuberculosis on a routine skin test (PPD); that is, I am a "PPD Converter." Apparently, I was exposed to the disease and am a carrier, although I have never had TB. Would this indicate that BCG treatment is not appropriate in my case? My reaction to the PPD test was actually rather severe - a lot of swelling, pain, and itching. I'd hate to think of something causing my bladder to react that way :(

BCG is not derived from TB, but is an organism in the same family as TB. It does not cause human infections under ordinary circumstances.
The PPD is a test that is designed to show a reaction if your immune system has been exposed to TB. I don't think that means your bladder will react the same way, but you should inform your urologist about your +PPD. If he is not sure whether or not it is an issue, consult an infectious disease specialist.

-Warren
TaG3 + CIS 12/2000. TURB + Mitomycin C (No BCG)
Urethral stricture, urethroplasty 10/2009
CIS 11/2010 treated with BCG. CIS 5/2012 treated with BCG/interferon
T1G3 1/2013. Radical Cystectomy 3/5/2013, No invasive cancer. CIS in right ureter.
Incontinent. AUS implant 2/2014. AUS explant...

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12 years 8 months ago #12214 by Rosemary
Dear D,

This reaction to a TB test should definitely be reported to your Doctor before undertaking BCG treatment.

BCG'a are LIVE, ATTENUATED TB Cells.

Better be safe than sorry.

Buds,
Rosemary

Rosemary
Age - 55
T1 G3 - Tumor free 2 yrs 3 months
Dx January 2006

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12 years 8 months ago #12211 by drosenberg
I have read that BCG is derived from a deactivated form of tuberculosis, or is related in some fashion to tuberculosis. Years ago, I tested positive for tuberculosis on a routine skin test (PPD); that is, I am a "PPD Converter." Apparently, I was exposed to the disease and am a carrier, although I have never had TB. Would this indicate that BCG treatment is not appropriate in my case? My reaction to the PPD test was actually rather severe - a lot of swelling, pain, and itching. I'd hate to think of something causing my bladder to react that way :(

Don

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