Chronic Bladder Wall Thickening

2 years 3 weeks ago #60948 by joea73
Replied by joea73 on topic Chronic Bladder Wall Thickening
I do not know much about direct relation between the thickening of bladder wall and cancer. But, I read that most of the time, bladder wall thickening is caused by inflammation, which is the result of immune response.   In this regard, though immune response is to kill pathogen or damages cells including cancer cells, I have noticed that recently more attentions are paid to  the other affects of  immune cells, that immune cells help cancer to grow.  They say immune cells form a part of tumor micro environment (TME) in the connective tissue and the cancer cells recruits  immune cells to help tumor grow.   For example,  immune check point PL-D1 protein which prevents T-cell to attack to kill cancer cell is often found in immune cells in addition to cancer cells.  In this case, immune cells in TME are helping cancer cells evade our immune cells (T-cells) from their attacks.  In this context,  it is known that immunotherapy, e.g. Keytruda is more effective for those with higher number of PD-L1 protein, which bladder cancer cell secretes out of the cell and  attach on the surface of the cancer cell.   PD-L1 helps cancer cell  evade our immune cell  (T cell) from its attack.  It turns out that  immune cells which are recruited which supposed to help attack the cancer cell are found to have PD-L1 protein.     So, when they check the eligibility of immune check point inhibitors such as Pembrolizumab (Keytruda) if it is going to work for the patient, the  pathologist who checks the patient's cancer specimens must count  PD-L1 on immune cells around cancer cells  and PD-L1 on cancer cells.   This may be an example, immune cells which cause inflammation, which also result in thickening of bladder lining (wall) help cancer growth.  But, those studies on the internet generally assume that the cancer cell is because of multiple gene mutations, and one of mutated gene is recruiting immune responses to help the cancer cell grow.  For example, a study which was published in Cell Journal in 2015 states  that in mice, PTX3 deficiency unleashes tumor promoting inflammation.  Tumors developed in a PTX3 deficient context have higher frequency of mutated Trp53.  Trp53 is the mouse version of TP53, which were identified in mutated form in muscle invasive and HG / CIS non-muscle invasive bladder cancer.   

In clinically though, yes, some chronic inflammation increases chance of cancer, eg.  Helicobacter pylon bacteria caused infection for stomach cancer and Chrone's disease which is chronic inflammation of bowel increases chance of cancer, but the chance of developing bladder cancer seems to be low.  For example.  Interstitial cystitis (IC) which is chronic inflammation condition of bladder has been shown to increase bladder cancer.   One study showed .32% of  IC patients  was diagnosed with bladder cancer and another study saw 6 out of 600 was diagnosed with bladder cancer during 3 years follow up.    When we compare the probability of being diagnosed with bladder cancer is  general population per 100,000, the demography of bladder cancer is as follows,, 0.2 0-19 yrs old, 1.1 20-39 yrs old, 17.1 40-59 yrs old 134 60-79 yrs old, 380 80+ yrs old according to one stats. If you are 65,  the chance of having the bladder cancer is 150/100,000 or 0.15%.  So, people with IC has twice more chance than general public to be diagnosed with bladder cancer according to the calculation.  Still we are talking about .32% chance if the bladder thickening is caused by IC.   Also, there are various effective treatment for bladder cancer especially in recent years if you happen to be one of 0.32% chance. 

Incidentally, you may want to ask your urologist to have urine analysis such as cytology regularly as surveillance protocol to detect bladder cancer if and when a tumor shows up.



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2 years 3 weeks ago #60947 by Jack R
Replied by Jack R on topic Chronic Bladder Wall Thickening

There are a number of non-cancer causes for bladder thickening. It is unfortunate that a search on "thick bladder" returns mostly cancer based replies.

Take a look at:

for a discussion of some of the non-cancer causes.

Because cancer is a possible cause, it is important to follow up and determine the actual cause and how to deal with it.


6/2015 HG Papillary & CIS
3 Years and 30 BCG/BCG+Inf
Tis CIS comes back.
BC clear as of 5/17 !
RCC found in my one & only kidney 10/17
Begin Chemo; Cisplatin and Gemzar
8/18 begin Chemo# 3
Begin year 4 with cis
2/19 Chemo #4
9/19 NED again :)
1/2020 CIS is back
Tried Keytruda, stopped by side effects
Workin on a new plan for 2021
The following user(s) said Thank You: Ford2004

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2 years 3 weeks ago #60945 by Ford2004
Chronic Bladder Wall Thickening was created by Ford2004
Good morning,I was diagnosed with Chronic bladder wall thickening. I have appointment with urologist next Wednesday but I’m so scared at this point as from what I’ve read it’s leading to cancer. Please feel free to share your stories and journeys. Anxiously looking for support.

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