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Pathology Report Interpretation

9 months 3 weeks ago #58493 by Ariver1
Sara Anne,

There is an additional comment section below. I’ve moved up our post op to 2 days from now, so we’ll know more then, but if you feel that you can comment on the below, that would be helpful. If not, I’m very grateful for any input. We’re bringing her back with us to the Philadelphia area after post-op to live, so any treatment will be lined up there. If you know of excellent cancer treatment facilities in that area, I’d like to look into them.

Comment: Sections show largely denuded urothelial mucosa with an
infiltrating neoplasm present in the lamina propria. The residual
overlying urothelium is unremarkable. The neoplastic cells have
eosinophilic cytoplasm and hyperchromatic nuclei. Nuclear pleomorphism is
noted. By immunostain, the neoplastic cells are positive for
pancytokeratin, and are weakly positive for GATA-3. They are negative for
CK7, CK20. This is likely an infiltrating urothelial carcinoma. A
metastatic carcinoma is not completely ruled out.

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9 months 3 weeks ago #58492 by sara.anne
I believe that there was not enough muscle tissue, if any, in the samples to tell if it had invaded the muscle. This is not uncommon, and often a second TURB it done now that the urologist knows where problem areas might be. Based on the other items in the path report he may not need to do this.

Sara Anne

Diagnosis 2-08 Small papillary TCC; CIS
BCG; BCG maintenance
Vice-President, American Bladder Cancer Society
Forum Moderator

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9 months 3 weeks ago #58490 by Ariver1
The pathology report from my Mom’s TURBT was just posted in her hospital health portal. While we have a post op appointment next week, I have a question about the reference below to the muscularis propria (detrusor muscle) adequacy: No. is this a positive or negative thing? I realize that the doctor will interpret the report and we go from there, but any comment on this initial report would be appreciated. I’m not going to share this with my Mom until the doctor does.

Tumor site: Urinary bladder.
Histologic type: Infiltrating carcinoma (see comment).
Histologic grade: Intermediate
Muscularis propria (detrusor muscle) adequacy: No.
Tumor extension: Invades lamina propria.
Lymphovascular invasion: No

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