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9 Replies
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Actually, I am not Katherine, but I am studying this cancer since I was diagnosed in November. And I am a biochemist so it’s easier for me to get the information through my University online library. Last link that I gave gives a comprehensive information about the BC. And it’s published this year. I will put this link separately in a thread.
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Katherine,
Thank you so much for your quick response and excellent research. Merry Christmas and God Bless you!!!
jw
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[quote=”seabreeze” post=47718]Katherine,
I just read the report mentioned above. My question is this – it appears there are 2 specific types of cancer of the bladder, one being invasive and one non-invasive. Two specific types. If non-invasive is left untreated does it turn into invasive or does it stay in the bladder lining?TY and GOD BLESS,
JW[/quote]
I found the answer to your question. “The rate of progression to muscle invasion or metastasis is 2% to 4% for grade I, 11% to 20% for grade II, and roughly 20% to 50% for grade III tumors. While grade tends to correlate with stage, high-grade Ta lesions are not substantially less dangerous than high-grade T1 lesions.” This is the link. http://www.ncbi.nlm.nih.gov/books/NBK12969/ -
I just read the original research paper to clear up your question again. Actually, they say that the exposure of mice to BBN (a carcinogen from the cigarette smoke)causes first the CIS tumor (in 3 to 4 months)and then further transformation (more mutations) leads to invasive BC. “evidence clearly demonstrates that basal urothelial stem cells expressing Shh (Sonic hedgehog protein) are the exclusive cell of origin for invasive bladder cancer, expression of Shh is lost by the time invasive carcinomas are formed. So, no mentioning of the non-invasive BC. Will be researching more to answer your question.
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thank you!!
JW
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I know for sure from reading other articles that the noninvasive can progress to invasive. The risk increases with high reccurency. My impression from this particular research (I maybe mistaken) is that the original mutated stem cell gave rise to precancerous lesions that were hedge hog expressing and the tumor was noninvasive. Further exposure to carcinogens transformed these originally hedge hog expressing cells to non hedge hog expressing cells and without this hedge hog signaling protein the cells became invasive. I actually read the original research paper a few months ago. But i forgot many details. This is a report based on that paper.
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Katherine,
I just read the report mentioned above. My question is this – it appears there are 2 specific types of cancer of the bladder, one being invasive and one non-invasive. Two specific types. If non-invasive is left untreated does it turn into invasive or does it stay in the bladder lining?TY and GOD BLESS,
JW
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Just a quote from the article in the upper link.
“So now we have two lines of evidence indicating that the bladder stem cells are solely responsible for tumorigenesis,” Shin said. “When we mark the bladder stem cells, the tumors are also marked. When we remove, or ablate, the stem cells, no tumors arise after BBN treatment.”
Next the researchers tackled the question of whether bladder cancers arise as the result of genetic changes to one or more of these bladder stem cells. To do so, they used a genetically engineered mouse with cells that fluoresce green, but which can be triggered to randomly fluoresce one of three other colors: red, blue or yellow. Known as a “rainbow mouse,” the animal allows researchers to more precisely determine the origin of groups of cells. If all cells in a tumor are red, for example, it is much more likely that they originated from a single cell.
“After four months of BBN treatment,” Beachy said, “we’d most often see just one color dominating the entire epithelium. This clearly indicates that a single cell has taken over the lining of the entire bladder, elbowing out its neighbors in a way that’s not been seen in other organs.”
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That’s an interesting read. Thanks for posting the link.
Best wishes… CatherineTURBT 1/21/10 at age 55
Dx: T2aN0M0 Primary Bladder Adenocarcinoma
Partial Cystectomy 2/25/10
Vanderbilt Medical Center
Nashville, TNSign In to reply.
