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Neo-Adjuvant Chemo
Just wanted to post this article that I read this morning! I think its good to read some positive outcomes, and if I’m honest I’m holding out hope my dad is in the 54%….It cheered up my dad when I read it to him this morning and it certainly gave me a boost!! Even if it only gets us through the chemo….its worth the research!!
Neo-adjuvant chemotherapy also provides an opportunity to consider bladder preservation in select patients who achieve a pathologic complete response. The MSKCC has reported on their experience with neo-adjuvant MVAC followed by bladder-sparing surgery for patients with muscle-invasive T2–T3, N0, M0 bladder cancer [30]. Of 111 patients undergoing neo-adjuvant chemotherapy followed by transurethral resection (TUR), 60 (54%) achieved a complete pathologic response (pT0). Of these 60 patients, 43 underwent bladder-sparing surgery (either TUR or partial cystectomy). After a median follow-up of 10 years, 74% of these patients are alive, with only 30% of patients developing an invasive recurrence. This study suggests that a pT0 afforded by neo-adjuvant chemotherapy may safely permit bladder-preserving surgery in select patients.
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