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    ITP chemo regimen

    Posted by kittylee on June 17, 2009 at 11:01 pm

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    My husband has recently started ITP (Ifex, Taxol, Carboplatin) chemotherapy for metastatic (liver, bones, lungs) bladder cancer. I’m having trouble finding studies or publications on the response rate, time to progression and survival rates for this combination. Can anyone help?

    I am a caregiver to my wonderful husband, Ron
    10/04 Multiple T1G3 – TURBT & 3 yrs BCG –
    9/08 Invasive BLC w/distant mets
    11/08 – 3/09 Gemzar/Cisplatin chemo regimen
    4/09 Radiation to bone mets
    6/09 lung and liver met progression – start ITP chemo
    10/09 My darling Ron passed away
    kittylee replied 15 years, 3 months ago 2 Members · 4 Replies
  • 4 Replies

  • kittylee

    Member
    June 18, 2009 at 12:44 pm

    You’re right, I’m afraid! I found some info on Medscape showing an overall response rate of 82% but duration of response was 1.5 to 11.7 months with an overall 18 month survival rate. The problem there, I suspect, is that it included a mixture of locally advanced and metastatic patients so I’m not sure how much weight that carries. My husband’s oncologist Doc, the enternal spring of optimism, stammered a bit, himself, when I asked him for the info. Thanks, bunches, for your well wishes.

    I am a caregiver to my wonderful husband, Ron
    10/04 Multiple T1G3 – TURBT & 3 yrs BCG –
    9/08 Invasive BLC w/distant mets
    11/08 – 3/09 Gemzar/Cisplatin chemo regimen
    4/09 Radiation to bone mets
    6/09 lung and liver met progression – start ITP chemo
    10/09 My darling Ron passed away

  • Guest
    June 18, 2009 at 3:48 am

    I wish someone had the answer Kitty..since the cancer is so widespread the combination your husband is being given is better tolerated than MVAC but to find stats on these trials is difficult……we really don’t have a second line of defense……
    In a phase II trial at Memorial Sloan-Kettering Cancer Center that included many patients with lymph node metastases, the ITP combination (ifosfamide, paclitaxel [Taxol], and platinum) yielded an impressive median survival of 18 months.

    Now thats kind of generalized isn’t it and i’m afraid thats about all i can find. Until they can look at that cancer under a microscope and determine what drugs will knock it out ???…….

    my best to you both…..Pat

  • kittylee

    Member
    June 17, 2009 at 11:42 pm

    Thank you, Patricia for that link. While I see where they mention the phase II study on ITP, I was unable to ascertain the information I noted in my original post. What did I miss?

    I am a caregiver to my wonderful husband, Ron
    10/04 Multiple T1G3 – TURBT & 3 yrs BCG –
    9/08 Invasive BLC w/distant mets
    11/08 – 3/09 Gemzar/Cisplatin chemo regimen
    4/09 Radiation to bone mets
    6/09 lung and liver met progression – start ITP chemo
    10/09 My darling Ron passed away

  • Guest
    June 17, 2009 at 11:22 pm

    read down to the Phase 11 study
    http://blcwebcafe.org/chemosused.asp
    pat

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