• Posted by wsilberstein on January 27, 2013 at 6:02 pm

    I have posted this on the non-invasive board but am posting this here as well in case you guys have a different perspective based on your personal experiences.

    For those of you who don’t know me a brief summary. I’m a pediatrician, diagnosed with TCC TaG3 + CIS 12 years ago. I was treated by TURB & intravesical mitomycin C. I developed a major problem with a urethral stricture which is when I learned about this support group and became a member. In 10/2009 I finally had a urethroplasty to repair the stricture just in time to deal with a recurrence of CIS after 10 years cancer-free. I was treated with BCG, and 1 year later had a recurrence of CIS treated with BCG/interferon. I had consulted specialists at Weill-Cornell and NYU, who agreed that this was a reasonable approach and that a recurrence after that would require a cystectomy. 6-7 months after my last set of biopsies and 3 months after BCG/interferon my biopsy shows high grade TCC with invasion of the lamina propria making it T1G3. My opinion is that this is a rapid enough progression to make it wise to get this bladder out before it becomes muscle invasive, even though it is not a recurrence of CIS (which I’m betting would happen within the year anyway). I have forwarded the biopsy reports to the specialist at NYU. I welcome your opinions. -Warren


    -Warren
    TaG3 + CIS 12/2000. TURB + Mitomycin C (No BCG)
    Urethral stricture, urethroplasty 10/2009
    CIS 11/2010 treated with BCG. CIS 5/2012 treated with BCG/interferon
    T1G3 1/2013. Radical Cystectomy 3/5/2013, No invasive cancer. CIS in right ureter.
    Incontinent. AUS implant 2/2014. AUS explant 5/2014
    Pediatrician
    mmc replied 11 years, 9 months ago 3 Members · 2 Replies
  • 2 Replies
  • mmc

    Member
    January 29, 2013 at 6:40 pm

    I agree with you Warren. I’m sure that is not a surprise as you know I tend to take a more aggressive treatment path than some. At this point you pretty much know which direction this is going.

    Read this if you have not already: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2684254/

    Mike


    Age 54
    10/31/06 dx CIS (TisG3) non-invasive (at 47)
    9/19/08 TURB/TUIP dx Invasive T2G3
    10/8/08 RC neobladder(at 49)
    2/15/13 T4G3N3M1 distant metastases(at 53)
    9/2013 finished chemo -cancer free again
    1/2014 ct scan results….distant mets
    2/2014 ct result…spread to liver, kidneys, and lymph system

    My opinions are my own and do not reflect the opinion of ABLCS or anyone else. I am not a doctor nor do I play one on TV.
  • nix

    Member
    January 29, 2013 at 10:17 am

    Hi Warren,
    You have given me so much information and support when I was dx’d six years ago. I
    am so sorry you have to go thru this, but knowing your resolve in the past, I know you will come thru this with flying colors!
    Please keep us posted, so we can “root you on” thru this process :)

    Nancy


    Nancy S
    Ta CIS
    dx Ta 11/06
    dx Ta CIS 10/07

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