-
Familial Bladder Cancer?
I’m probably posting in the wrong section again, but here goes…
Does anyone know of any evidence of bladder cancer being hereditary? My dad died of bladder cancer two years ago and we just found out (he never even knew) that his maternal grandfather also had bladder cancer. Heart attack is listed as the cause of death on his grandfather’s death certificate – which we just found – but bladder cancer was also listed.
Just curious and a little worried!
Thanks,
Debi -
23 Replies
-
Warren
Thanks for that- as I thought it’s high in some veg- love asparagus, and get quite a bit of what’s on those lists, but it looks like I might need to up the bean intake! Hmmm. ::)
Anne
-
This is a very interesting discussion. I remember, a couple years ago reading about a certain gene in family members AND if they are also smokers a corralation for bladder cancer has a high possibility of occurring. I have alerted my four younger brothers who are smokers to have their urine tested since their older sister (me)has had superficial papillary bladder cancer. Since Rosemary’s posting of the gene and Warren’s comments on the subject I did a search on Yahoo and learned that gene can be the cause of all types of diseases. As far as folate is concerned, the current recommendation is for 400 units but my daughter who is a Registered, Licensed Dietician and others in that nutrition category say the intake should be a minimum of 800 daily. Here is the website that shows lots of different diseased attributed to that MTFHR gene.
http://www.ihop-net.org/UniPub/iHOP/bng/90334.html?list=0 Rosie -
Thanks for the link – I do eat a healthy diet, but have wondered if I should take a supplement while fighting Bladder Cancer. I am sure I get the daily dose with my diet, but still pondering adding more. ???
Nancy S
Ta CIS
dx Ta 11/06
dx Ta CIS 10/07
[quote author=annec link=topic=1709.msg12719#msg12719 date=1200851262]
Can anyone shed some light on the “folate intake” mentioned- it seems from what has been quoted that if it is familial in your family, than an increased folate intake would be a good idea. Is this the same as folic acid? and what can it be found in naturally? Green leafy veg?
[/quote]
Dear Anne,
Folate and folic acid are the same thing. Check the information at
http://ohioline.osu.edu/hyg-fact/5000/5553.html and
http://grove.ufl.edu/~folic/info/folatesources.html
for more information.
-Warren
TaG3 + CIS 12/2000. TURB + Mitomycin C (No BCG)
Urethral stricture, urethroplasty 10/2009
CIS 11/2010 treated with BCG. CIS 5/2012 treated with BCG/interferon
T1G3 1/2013. Radical Cystectomy 3/5/2013, No invasive cancer. CIS in right ureter.
Incontinent. AUS implant 2/2014. AUS explant 5/2014
Pediatrician
Can anyone shed some light on the “folate intake” mentioned- it seems from what has been quoted that if it is familial in your family, than an increased folate intake would be a good idea. Is this the same as folic acid? and what can it be found in naturally? Green leafy veg?
Anne
Well if it is hereditary then I am the first in my family tree to start it. I don’t believe BC is hereditary just unlucky to get. Cheers, Joe ;)
For what it’s worth, my father died from bladder cancer four years ago during the time that I was being treated. His illness was much more advanced when it presented but, still, I think it had a part to play in my cystectomy decision. My doc said their was no hereditary link known.
Gman,
Thanks for the info on bladder cancer and heredity. I certainly plan on doing more research as this is very worrisome to me.Also, please know I will keep you in my prayers. I hate this dreadful disease, but such much can be done to keep it contained. Follow your gut feelings and stay strong!
Debi
Well actually i meant you and your brother as one and Carolyn the nurse who just got her neobladder from Dr. Koch in Indianapolis…she has an identical twin sister.
That is a rather good name for that gene!! Pat
Dear Rosemary,
Oops! :-[ And I tried to get the link right so it would make things easier :P, but the other article was good too.
Not raining on LI today, but not so nice.
-Warren
[hr]
Dear Pat,
Another set of twins here? How did I miss that? I always enjoy comparing notes with other twins.
-Warren[hr]
P.S.: My niece & my brother had another fun name for the MTHFR gene. Use your imagination because I can’t put it on a public forum.
P.P.S.: The MTHFR gene had us worried, but the baby is just fine – 6 months old and adorable.
-Warren
TaG3 + CIS 12/2000. TURB + Mitomycin C (No BCG)
Urethral stricture, urethroplasty 10/2009
CIS 11/2010 treated with BCG. CIS 5/2012 treated with BCG/interferon
T1G3 1/2013. Radical Cystectomy 3/5/2013, No invasive cancer. CIS in right ureter.
Incontinent. AUS implant 2/2014. AUS explant 5/2014
PediatricianWhat i find interesting is that i have now seen two sets of identical twins on this forum..of which..only one of the twins has bladder cancer in each case…..obviously they have the identical genetic make-up but environmental differences….so is anybody studying identical twins? Pat
I just noticed the word “stongly” in the following quote from the referenced link…I wonder why this isn’t talked about/researched a little more???
Our results [glow=red,2,300]strongly[/glow] suggest that polymorphisms of the MTHFR and MS genes act together with low folate intake and smoking to increase bladder cancer risk. These results have important implications for cancer prevention in susceptible populations
http://carcin.oxfordjournals.org/cgi/content/full/25/9/1639
Rosemary
Age – 55
T1 G3 – Tumor free 2 yrs 3 months
Dx January 2006
Actually, it was here…
http://carcin.oxfordjournals.org/cgi/content/full/25/9/1639
I guess I didn’t read the fine print…..I still don’t understand it…
It would be interesting, Warren, to find out if you have the gene….
It’s dreary here today. I hope it’s sunnier on LI.
Buds,
Ro
Rosemary
Age – 55
T1 G3 – Tumor free 2 yrs 3 months
Dx January 2006
Interesting!! Thanks….
Ro
Rosemary
Age – 55
T1 G3 – Tumor free 2 yrs 3 months
Dx January 2006
[quote author=Rosemary link=topic=1709.msg12683#msg12683 date=1200757330]
Can you please clarify for me which gene is the MTHFR???
[/quote]Don’t know much about it. It was in the article about polymorphisms of folate metabolism genes that you refered to at http://www.emedicine.com/med/topic2344.htm
It’s apparently tested for in pregnancy because folate helps prevent neural tube defects and having the gene makes your folate requirement higher. Since the article said it was a risk factor for cancer, and since my niece carries it, I couldn’t help but wonder if she got it from her mother or my twin (which would mean I have it).
-Warren
TaG3 + CIS 12/2000. TURB + Mitomycin C (No BCG)
Urethral stricture, urethroplasty 10/2009
CIS 11/2010 treated with BCG. CIS 5/2012 treated with BCG/interferon
T1G3 1/2013. Radical Cystectomy 3/5/2013, No invasive cancer. CIS in right ureter.
Incontinent. AUS implant 2/2014. AUS explant 5/2014
PediatricianSign In to reply.
