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Chemo before or after surgery for high-risk bladde
Chemo before or after surgery for high-risk bladder cancer improves survival, but is not routinely administered. April 14, 2014
http://www.sciencedaily.com/releases/2014/04/140414092119.htm
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10 Replies
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My hematologist said that there were too many lymphoid masses, so they described them. when during the treatment all lympho-masses were gone, they noticed a mass in the bladder. They compared with previous scans and said that this mass did not shrink. So it has to be TCC.
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OMG! I guess that is why we need to be our own advocate. What did they say how was it overlooked? Hopefully you are getting the proper care now.
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No, they were not. Moreover, they missed it on previous ct scans, only on the last one in Oct they noticed it. Later they told me that it was there on previous scans. I could have had my first turb in March last year or even before that.
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Yes, I believe they are working diligently to found other options, not sure that we can expect this in the very near future.
I have a question several on this site and others had NHL first and later was diagnosed with bladder cancer. I did see the use of cumulative doses of cyclophosphamide and, to a lesser extent, to radiotherapy might be a cause. Were they monitoring you for bladder cancer based on the use of cyclophoshamide?
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I watched two webcasts about cancer stem cells ( CSC) that cause recurrence and invasion. Until we learn how to kill them we will be loosing our bladders and other organs. At NCI they have a list of organs that we can live without. Obviously, bladder is on that list. The good news is that there are agents that can kill CSCs preferentially. In one webcast they used activated natural killer cells of our immune system with chemo to successfully kill them. In the other webcast they found a bunch of chemical compounds that can kill them. The clinical tests are being conducted on animal models.
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Thank you Sara Anne, hopefully one day in the near future the bladder can be saved.
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Anne, since the bladder lining has been “transformed” and is unstable with regard to tumor formation, and has demonstrated this either by spreading into the muscle layers or by repeated returns, chemo (which might attack current tumors) would not be effective in halting the cancer in the bladder itself.
The purpose of chemo prior to bladder removal is to destroy any micro-seeding of metastises outside the bladder. Since bladder removal is major surgery, and requires a relatively long recovery time, chemo given before bladder removal is more efficient than waiting six months or more.
Occasionally, once the bladder is removed and analyzed, it is found that there is more likely to be a spread of the cancer than was originally thought, and chemo is done after the trauma from the cystectomy has healed.
Sara Anne
Diagnosis 2-08 Small papillary TCC; CIS
BCG; BCG maintenance
Vice-President, American Bladder Cancer Society
Forum Moderator
Wonder if anyone does the chemotherapy,and doesn’t remove their bladder. I would like to know statistics on the recurrence. I know bladder removal is the gold standard treatment.
I see that people from our club are getting chemo before surgery for invasive types. Glad, they get the best treatments, but sad they have to loose their bladder.
Very interesting article, seems like most are not follow ing this I question why ..
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