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BCG Plus Interferon

8 years 4 months ago #33402 by Patricia
Hi Brenda...this from Medscape
Combination immunotherapy, specifically the use of BCG plus interferon alfa 2b, is highly effective. About 60% of patients who fail to respond to BCG can be rescued with BCG plus interferon (O'Donnell, Krohn, & DeWolf, 2001). The standard dose is 50 mg to 81 mg of BCG plus 50 million units of interferon alfa 2b. Treatments are given weekly for 6 weeks, with maintenance using up to 3 weekly instillations at 3 or 6 months, and then every 6 to 12 months. The dose of BCG is reduced to 1/3, 1/10, 1/100 as needed to prevent increased side effects. While we try to avoid giving a second 6-week course of BCG to patients who have previously received BCG because they are at risk of immunosuppression, the addition of interferon appears to reduce this risk.
And if that doesn't rescue you know what to do.
Best to you

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8 years 4 months ago #33400 by bmathews9744
I start my second round of BCG next week. The first 6 week course worked for getting rid of the tumor Ta Grade 3 but not the CIS. The second round of BCG will have interferon added.

Does anyone have any experience with this ?


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