I was asked about this just the other day and did some research and this is what I found.
Mitomycin for injection is listed by the FDA as being a drug there is shortage of. I investigated and I believe the story to be that of the two manufactures’ of it one sold the manufacturing rights to an Indian company and that is causing the current situation.
I wrote Dr. Lamm one of our medical advisors and considered by many to be the father of BCG and this is what he generously shared. My question was did he have any suggestions for substitutes? Your Uro would need to contact him for specifics such as dwell times and dosage and I have included a link to his website.
Absolutely! There are several other intravesical chemotherapies that are
effective, many cheaper than MMC. Doxorubicin is good, as
is Thiotepa. Valrubicin should be commercially available soon.
New, not yet approved but clearly effective drugs include docetaxel and gemcitabine .
This was taken from an abstract for UroToday the presentation was given for the 09 AUA. Dr. O’Donnell did not mention exact amounts but I included his contact page. I am sure if a Urologist was to inquire he would share the specifics.
Dr. O’Donnell said no to random biopsies as the yield if 5% or less. He said yes to immediate intravesical chemotherapy, which gives an 11% absolute reduction in recurrence from 47% to 36%. With the Mitomycin shortage presently in the US, one could use adriamycin.
I received this from a new user and I am posting it for general information because this could be a problem for more than just her husband.
My husband was diagnosed with bladder cancer in January of 2008. Since that time he has undergone several surgeries and rounds of BCG treatments. He did not respond to these treatments. He was supposed to start a new chemo called Mitomycin. He has been told that this medicine is nationally out of stock. Does anyone know anything about this? Please advise back. Thanks
T2 g3 CIS 8/04
Chemotherapy & Radiation 10/04-12/04
RC w/umbilical Indiana pouch 5/06
Left Nephrectomy 1/09
President American Bladder Cancer Society