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cox 2 inhibitors

10 years 1 month ago #22218 by orpheus
Hi Rosemary, I knew you would have something about this! Fascinating, thank you. Orph

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10 years 1 month ago #22205 by Rosemary
Sara Anne,

Well, the thing is that the plug was pulled on the Clinical Trials for using Celebrex as a Chemo Agent in the treatment of Bladder Cancer.
So, I can't really answer the question. I doubt that you will find a Doctor who will prescribe Celebrex for Bladder Cancer because as far as I know the FDA would not approve it because it is not indicated as treatment for this disease (because the Clinical Trials were stopped)...

But, it does seem that it is being used for other cancers, and as Patricia's link indicated (O'Donnell)states that it might be of great help to us.

What can we do??? Should we be asking our Dr's about it? Like others stated, they seem to be getting the brush off when asking about it....

BTW, I am taking 400 milligrams of Celebrex a day...but it is for treatment of my psoriatic arthritis...

Thanks for the interesting link, Pat....

Rosemary
Age - 55
T1 G3 - Tumor free 2 yrs 3 months
Dx January 2006

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10 years 1 month ago #22201 by sara.anne
I think this is exciting. Rosemary, what is the doseage for the Celebrex? Just like for arthritis? And just during the treatment?
I had some real arthritis problems several years ago and found that Celebrex helped. Then the big scare. I have been taking fish oil for several years and it, or something, has really reduced the arthritis pain. And no, BCG didn't bring it back.

Sara Anne

Diagnosis 2-08 Small papillary TCC; CIS
BCG; BCG maintenance
Vice-President, American Bladder Cancer Society
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10 years 1 month ago #22194 by Patricia
Well the most recent article is May 2008.....so i don't think they've abandoned it quite yet and Dr. Pruthi (Rosemarys doctor) was one of the initial investigators. This from O'Donnell another leader in the blc world.
http://www.medicalnewstoday.com/articles/109408.php
Pat

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10 years 1 month ago - 10 years 1 month ago #22193 by Rosemary
Here is the report of the medicines being used in the treatment of Ted Kennedy's brain tumor and the explanation of the action of the Cox 2 Inhibitor...

"Better understanding of abnormal gene behavior has ignited optimism in a field that is all too often grim. Abnormal genes can point to specific biochemical targets that make other chemo agents good bets. For example, some gliomas lack a different gene, which causes them to overproduce a protein called EGFR. New drugs that block this protein and are already approved for other cancers have produced dramatic shrinkage in some gliomas bearing that genetic error. And other genes are targets too, including ones that affect inflammation, blood vessel growth, and even vitamin A metabolism. Yes, some commonplace drugs like Celebrex (which blocks the COX-2 inflammatory pathway) and Accutane (an acne drug similar to vitamin A) might find themselves in a standard glioma treatment cocktail, depending on the nature of the tumor."


http://health.usnews.com/articles/health/cancer/2008/06/03/ted-kennedys-expanded-cancer-arsenal.html

Rosemary
Age - 55
T1 G3 - Tumor free 2 yrs 3 months
Dx January 2006

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10 years 1 month ago - 10 years 1 month ago #22192 by Rosemary
Orpheus,

I can give you the answer that my Rheumatologist gave to me.

I asked him about the role of Celbrex as a chemo agent to suppress bladder cancer. This particular Doctor got really excited and told me that Celebrex has been proven to help with Colon Cancer also. He told me a story about a Doctor at Duke who is treating a very famous person (okay, it's documented on the net, the person is Ted Kennedy) with a brain tumor with Celbrex and that it was helping...

The way he described it to me is that Celbrex helps with tumor angeogenesis.
He said that means that Celebrex helps to cut off the blood supply to the tumors...

That's what he said...

Ro

Rosemary
Age - 55
T1 G3 - Tumor free 2 yrs 3 months
Dx January 2006

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