Ro...it sounds like its from the tumor.....from original turbs. But any new markers they come up with i guess is progress??? Whether it is something that will be used here at major centers??...Why not ask Dr. Pruthi about the paper...i am awaiting a reply from MSK and Cleveland.....but that may take a while as it never gets to the right person. I did notice if you google the biomarker Ezrin ..it is used in a ton of cancers as a prognosticator?...
apparently patterns of Ezrin are markers in progression according to this paper. If you can't access just sign in...its free..and say you're a medical consumer.