sara anne......
Cystitis cystica glandularis is a rare disease, caused by metaplasia of the vesical submucosa, probably related to a chronic irritative factor.[1] Some investigators believe that this condition reflects mobilisation of the humoral immune defence response by various agents.[2] In its minor form, it has the same clinical features as simple cystitis, but its major pseudoneoplastic form may be clinically mistaken for bladder tumour. Cystitis cystica glandularis is considered to be a premalignant disease of the urinary bladder as some reports document its progression to adenocarcinoma. It has also been reported to occur frequently in association with pelvic lipomatosis.[3] Cystoscopic biopsy is mandatory, as the diagnosis is essentially histological. It appears histologically as submucosal nests of columnar epithelial cells surrounding a central liquefied region of columnar degeneration. In the absence of obvious lesion, treatment is usually medical, based on the eradication of the irritative factors. Surgery is required in case of complications of the disease like recurrent haematuria or features associated with bladder outlet obstruction secondary to the pseudoneoplastic growth. The surgical approach includes transurethral resection of the lesion (TUR) or laser ablation.[4],[5] The clinical course is unclear and requires long-term surveillance