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If 870+/-1116 mm3/mo is the growth rate of a bladder what that in mm per month?

7 months 1 week ago #55270 by jones
Hi Jack, Great analysis of the article. Puts into total perspective now. Thanks for your expertise.

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7 months 1 week ago #55268 by Jack R
Jones

Thank you for the link to the article you summarized.

As is usually the case, the meaning to be taken from reliable medical articles is in the details.

There is a great deal more to consider than just, "The rate of tumor growth during the watchful waiting period depended highly on the tumor's largest diameter at the beginning of surveillance".

The participants in the study ALL initially presented with a low grade (G1) papillary tumor of less than 10 mm, had negative cytology, and a TURBT. Surveillance (aka they were followed) with a 3 cystoscopy every 3 months. The initial size of any NEW tumor, found at a three months point was noted and followed. All new tumors were sent to pathology.

For this very small (28 patients) select group, cleared of low grade tumors by TURBT, and closely monitored, the authors suggest that the growth rate of newly emergent tumors could be a useful metric for HELPING TO determining how to determine individual treatment plans for the tumors. The authors recommended additional studies be conducted.

So, it is the details that matter. In this well defined situation, differences in growth rate SOMETIMES can identify tumors that have advanced from Grade 1 to Grade 2 and may require more aggressive treatment.

What's with this Bleeding ? 6/2015
DX: HG Papillary & CIS
3 Years and 30 BCG/BCG+Inf
T0 CIS comes back.
BC clear as of 5/17 !
RCC found in my one (only) kidney 10/17
Begin Chemo; Cisplatin and Gemzar
8/18 begin Chemo , round 3
Begin year 4 with cis T0

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7 months 1 week ago #55266 by jones
Hi, yes. Here is the article: https://www.ncbi.nlm.nih.gov/pubmed/16413659

https://www.ncbi.nlm.nih.gov/pubmed/16413659

Eur Urol. 2006 Feb;49(2):303-6; discussion 306-7. Epub 2006 Jan 6.
Watchful waiting policy in recurrent Ta G1 bladder tumors.
Gofrit ON1, Pode D, Lazar A, Katz R, Shapiro A.
Author information
1
Department of Urology, Hadassah University Medical Center, Jerusalem, Israel. This email address is being protected from spambots. You need JavaScript enabled to view it.

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7 months 1 week ago #55265 by jones
Hi, yes. Here is the article: https://www.ncbi.nlm.nih.gov/pubmed/16413659

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7 months 1 week ago #55257 by Jack R
Jones,

Can you provide the URL to the article ?

It seems rather amazing that there is a 200 TIMES increase in growth rate based ONLY on the initial observed tumor size, at the brightline demarcation size of 5 mm.

The HeLa cell line being, perhaps, an exception.

I would love to see the original article

What's with this Bleeding ? 6/2015
DX: HG Papillary & CIS
3 Years and 30 BCG/BCG+Inf
T0 CIS comes back.
BC clear as of 5/17 !
RCC found in my one (only) kidney 10/17
Begin Chemo; Cisplatin and Gemzar
8/18 begin Chemo , round 3
Begin year 4 with cis T0

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7 months 1 week ago #55240 by jones
Hi Jack, thanks! It's from an article about bladder tumors, it says: The rate of tumor growth during the watchful waiting period depended highly on the tumor's largest diameter at the beginning of surveillance. If the initial tumor diameter was smaller than 5 mm (32 cases), the tumor growth rate was 4+/-5.1 mm3/mo (mean+/-SD); if the initial tumor diameter was > or =5 mm (6 cases), the tumor growth rate was 870+/-1116 mm3/mo (p < 0.05).

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