First let me say welcome. You are in my prayers!! This is not an easy process for you nor any of us who have been diagnosed. I remember all to well like it was yesterday. This website is the best place for knowledge and support. I will be praying for you!! Keep us posted.
DX April 2014 5cm tumor
Stage 1 Grade 3 BC
6 bcg treatments
Thank you very much!! I did get my biopsy results back and they were negative!! So my anxiety has been relieved. However, the office did not mention anything about the Fish test that they did. I guess I will ask when I go back for my next cystoscope in January. I will start another round of BCG after that visit. So for now I'm going to stay positive and try not to think about anything. If only my bladder would stop misbehaving. I have severe frequent urination and pain still, especially at night and I am on a medication to help but it is not helping. I probably shouldn't complain as it could be worse.
FISH Testing from Urine Samples May Predict Risk of Cancer Progression in Patients with Superficial Bladder CancerFISH Testing from Urine Samples May Predict Risk of Cancer Progression in Patients with Superficial Bladder Cancer
According to a recent article published in the Journal of Urology , laboratory testing (referred to as fluorescence in situ hybridization (FISH)) from a urine sample in patients with superficial bladder cancer may help predict a patient’s response to therapy, as well as their risk of developing more advanced disease. Patients who are at an increased risk of progressive cancer may wish to undergo more aggressive therapy than their counterparts.
Bladder cancer is a common cancer, with approximately 55,000 new cases diagnosed in the United States each year. Superficial bladder cancer refers to cancer that remains localized within the outermost (most superficial) layers of the bladder and has not spread to deeper layers of the bladder. Patients with superficial bladder cancer are routinely treated with surgical removal of the cancer followed by additional (adjuvant) therapy to decrease the risk of recurrent cancer or progression to more invasive disease. Despite standard treatment, many patients with superficial bladder cancer experience a recurrence of their cancer. Following the removal of the cancer, patients with superficial bladder cancer are usually treated with adjuvant intravesicle chemotherapy (placement of the drug directly into the bladder), which often consists of mitomycin C or Bacille Calmette-Guérin (BCG). While this therapy is beneficial, recurrences are common, and a substantial portion of patients will ultimately develop more advanced disease. Therefore, patients undergo routine and sometime frequent monitoring, often in the form of a cystoscopy, a procedure in which a lighted tube is inserted into the bladder. Due to the invasiveness of this procedure, as well as the time and financial commitments for patients to undergo cystoscopies, researchers are evaluating other ways in which to monitor recurrences or predict patients who are at a high risk of developing more advanced disease. These patients may wish to undergo more aggressive therapies to reduce their risks and improve their long-term outcomes.
Researchers from the Mayo Clinic recently conducted a clinical trial to evaluate the accuracy of FISH testing of urine samples in patients with superficial bladder cancer. FISH testing includes laboratory measures to determine if specific abnormal cells are present in the urine. This trial included 37 patients with superficial bladder cancer who were undergoing intravesicle therapies with BCG or other therapies. Urine samples and FISH testing were performed prior to therapy, as well as following therapy, and were compared to results of standard testing procedures. Post-therapy FISH results included 25 patients with normal (negative) results and 12 patients with detection of abnormal cells (positive results). All patients with positive post-therapy FISH results experienced a cancer recurrence, while only 13 of the 21 patients with negative post-therapy FISH results experienced a cancer recurrence. Importantly, patients with a positive post-therapy result were at a 9.4-fold increased risk for developing more advanced (muscle-invasive) bladder cancer and 75% of patients with positive FISH results both pre- and post-therapy eventually developed muscle-invasive bladder cancer.
The researchers concluded that FISH testing of urine samples in patients with superficial bladder cancer undergoing intravesicle therapy can help predict the risk of a cancer recurrence or the risk of developing a more advanced form of cancer. Patients at a high risk of developing more advanced cancer may wish to undergo more aggressive therapy in the hopes of improving long-term outcomes. Patients with superficial bladder cancer may wish to speak with their physician about the risks and benefits of participating in a clinical trial further evaluating urinary FISH testing or other non-invasive screening methods. Two sources of information regarding ongoing clinical trials include the National Cancer Institute (cancer.gov) and www.cancerconsultants.com. Personalized clinical trial searches are also performed on behalf of patients at cancerconsultants.com.
Wish I could give u sum info I'm currently as we speak getting my scope done waitin my my dr in the hospital now who's running late..
Had cat scan done after 2 months of what thought was uti infections meds didn't wk had cat scan found thongs in my bladder & here I am .. idk what to think or expect what is my chances it's just stones. . I hope ur news was good.. God bless
The FISH test is a cell test that is usually done for prostate cancer. i guess it can be used for bc.
It measures cancer cells. If the number is too high, then they have to look further.
I have a FISH test each time I go in for my annual checkup at the urologist.
This is normal. Don't be alarmed by it
Light a man a fire and he is warm for an evening.
Light a man ON fire and he's warm forever.
08/08/08...RC neo bladder
New Man! [/size]
The FISH test is an abbreviation for a urine test to see if there abnormal cells. It often can give false positives thus the cystoscope is almost always done in conjunction. Cytology and/or FISH just gives you more information.
DX 5/6/2008 TAG3 papillary tumor .5 CM in size. 2 TURBS followed by 6 instillations of BCG weekly with a second round of 6 after a 6 week wait.