From what I see here, Mike is right, specimen did not survive processing so no one knows what was there at the time of the initial biopsy. As to NMP-22, cytology and cystoscopy; cystoscopy is the gold standard for diagnosis of bc. There are false negatives, but I doubt as high as 30% unless the study group is limited to only certain categories of patients. Cytology is quite good with high grade lesions, perhaps better than any of the surrogate tests (such as NMP and others), but is not as good with low grade lesions. The specificity of cytology is better than the surrogate tests (meaning that a positive is more likely to be bc in the case of positive cytology than positive surrogate (such as NMP). Nmp false positives seem to be higher in cases of bladder inflammation. I also believe that adding the fluorescent aspect to cystoscopy greatly improves its sensitivity (ability to detect lesions) particularly for CIS. Best wishes,
The initial post said that the sample was destroyed before there person when to the Herr. Maybe I misinterpreted but I'm not sure how Herr can find anything if he's not given anything to look at.
If there was CIS but it was destroyed and there was no pathology to analyze, and if the there isn't any visible CIS still in the bladder, then I would guess that Herr would want to be on the safe side and therefore set up a surveillance schedule to keep an eye on things.
Maybe there were slides, but the message didn't indicate that...
It may have ruled out residual cancer but who knows about the original issue? It could have been CIS, which has a high recurrence rate so you want to be on monitoring. I'm not sure how they could rule out bladder cancer given the red spot could have been CIS but was destroyed prior to pathology analysis.
I know about NMP-22. They did both cytology and NMP-22 tests on my urine. Pat can probably point you to the research on which is better.
The blue light is supposed to be much better than the white light at seeing things.
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osiag.....well you got the premier Bladder cancer specialist...he got all of mine out plus margins and with white light...i would be very surprised if he missed something especially using the newer technology.plus he did a urogram which would wash out any stray cells. Its good that he's going to follow through in December. Microhematuria can happen in some cases and they never find the cause. It happens a lot with runners, people who exercise heavily.....or for no particular reason. I think you're in good hands.
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